Enhancement of Tumor Response to -Radiation by an Inhibitor of Cyclooxygenase-2 Enzyme
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چکیده
منابع مشابه
Re: Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme.
Milas and co-workers (1) reported in a recent issue of the Journal a potential adjuvant effect of selective cyclooxygenase-2 (COX-2) inhibition on tumor response to radiotherapy in an animal model. These authors postulated that the COX-2 inhibitor 4-[5-(4-chlorophenyl)3-(trifluoromethyl)-1H-pyrazol-l-yl)] benzenesulfonamide (SC-8236) is able to enhance response of the mouse sarcoma NFSA to loca...
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Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types of malignant tumors, where it mediates production of prostaglandins (PGs), which in turn may stimulate tumor growth and protect against damage by cytotoxic agents. This study investigated whether SC-'236, a selective inhibitor of COX-2, potentiates antitumor efficacy of radiation without increasing ...
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The antitumor effects of the selective cyclooxygenase (COX)-2 inhibitor SC-236 alone and in combination with radiation were investigated using the human glioma cell line U251 grown in monolayer culture and as tumor xenografts. On the basis of Western and Northern blot analyses, these cells express COX-2 protein and mRNA to levels similar to those in the human colon carcinoma cell line HT29. Tre...
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Photodynamic therapy (PDT) continues to be used in the treatment of solid tumors. Clinical results are promising, but the therapy has not been optimized, and tumor recurrences can occur. Recently, it has been shown that inhibitors of cyclooxygenase (COX)-2 can be effective in combination with conventional chemotherapy and radiation therapy. In the current study, we examined the parameters of PD...
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Introduction: It has been shown that the extract of Elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. The aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of Elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (Cox) type ...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1999
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/91.17.1501